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Structure of human telomere G-quadruplex in the presence of a model drug

G-rich DNA sequences are able to fold into structures called G-quadruplexes (G4). 

These structures are the focus of a number of studies in both fundamental and applied research, from cancer biology and novel therapeutics through to nanotechnology. A multi-technique approach, combining circular dichroism spectroscopy, Synchrotron-based UV Resonance Raman spectroscopy and small angle scattering techniques, has been deployed to elucidate how the structural features of the human telomeric G-quadruplex Tel22 change upon thermal unfolding.
 

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Nucleic Acids Research, Vol. 46 - 22, pp. 11927-11938 (2018) 
Last Updated on Thursday, 30 May 2019 11:22