Pore flexibility underlies the poor selectivity of CNG channels: a structural, functional and computational analysis.
In contrast with what observed in the rigid potassium channel structures, we saw a significant variation of the pore and the surrounding regions in the presence of different ions, showing that CNG channels are flexible and can accommodate small and large ions with different geometries.Napolitano LMR et al., Proceedings of the National Academy of Sciences, Vol. 112 - 27, pp. E3619-E3628 (2015)
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Cyclic nucleotide-gated (CNG) channels play important roles in transmitting information about vision and smell from sensory cells to the brain, and share a high degree of similarity with K+ channels. Whereas K+ channels discriminate with high accuracy Na+ from K+, CNG channels do not discriminate among different cations. By combining electrophysiology, molecular dynamics simulations and X-ray crystallography we found that the pore region exhibits a dynamic structure and the pore diameter critically depends on the ion within. |
Retrieve Article A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels, Napolitano LMR, Bisha I, De March M, Marchesi A, Arcangeletti M, Demitri N, Mazzolini M, Rodriguez A, Magistrato A, Onesti S, Laio A, Torre V Proceedings of the National Academy of Sciences, Vol. 112 - 27, pp. E3619-E3628 (2015), doi: 10.1073/pnas.1503334112 |
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