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X-ray-based methods to model the release of a highly water-soluble drug from lipid microspheres

The present study deals with systems dedicated to oral administration and able to prolong or extend the delivery of drugs at predictable and reproducible rate, for a period defined by the control of their release kinetics. Several control drug delivery systems have been investigated, highlighting different release mechanisms.

 P. Pivette “Controlled release of a highly hydrophilic drug from lipid microspheres obtained by prilling: analysis of drug and water diffusion processes based on X-ray methods”, Journal of Controlled Release 158, 393, (2012), doi: 10.1016/j.jconrel.2011.11.027.

Modified-release drug delivery systems have been increasingly developed mainly to avoid repeated administration and then limit fluctuations in plasma drug concentrations as well as to improve bioavailability. Release-modified dosage systems provide complementary benefits, especially reduced side effects, greater convenience, facilitated compliance of the treatments and drug protection prior to release. The present study deals with systems dedicated to oral administration and able to prolong or extend the delivery of drugs at predictable and reproducible rate, for a period defined by the control of their release kinetics. Several control drug delivery systems have been investigated, highlighting different release mechanisms. These controlled release devices, include on one hand reservoir-like systems which consist of an inner core containing the drug surrounded by a water-insoluble shell, and on the other hand, matrix systems which directly embed the pharmaceutical ingredients within materials which directly regulate the water inflow and the drug outflow. In the field of matrices, lipids generate special interest due to their biocompatibility and lower toxicity, and since they are highly hydrophobic and show rather low melting temperatures suitable for melt processing techniques. The release process of an active pharmaceutical ingredient (API) from a matrix system depends on the physico-chemical properties of the constituents and from their interactions with the release medium too.

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Perrine Pivette, Vincent Faivre, Lucia Mancini, Claire Gueutin, Georges Daste, Michel Ollivon, Sylviane Lesieur, “Controlled release of a highly hydrophilic drug from lipid microspheres obtained by prilling: analysis of drug and water diffusion processes based on X-ray methods”, Journal of Controlled Release 158, 393, (2012), doi: 10.1016/j.jconrel.2011.11.027.
Last Updated on Tuesday, 17 September 2013 10:02