Polymorphism of human telomeric quadruplexes with anticancer drugs: a multi-technique biophysical study

quadruplexIdentification of small molecules able to stabilize telomeric G-quadruplexes is an attractive target for cancer therapy. Knowledge of quadruplex folding and structural polymorphism is required for structure-based rational drug design.

Elettra's contribution

A multi-technique approach, combining circular dichroism spectroscopy, synchrotron-based UV resonance Raman spectroscopy and small angle scattering techniques has been effectively used to provide insights into structural and molecular aspects of the interactions between polymorphic human telomeric quadruplexes and different molecules under different environmental conditions.

The results demonstrate that this methodology could be also relevant for anti-cancer drug discovery, by designing and tailoring molecules able to form stable complexes with DNA.

Facility: SAXS and IUVS Beamlines.

Bibliography: L. Comez et al., “Polymorphism of human telomeric quadruplexes with drugs: a multi-technique biophysical study”, Phys. Chem. Chem. Phys., 2020, 22, 11583. DOI: 10.1039/D0CP01483D.

Last Updated on Friday, 03 June 2022 12:19